Bile Salts Pregnancy. Pruritus plus raised total bile acids in the third trimester suggests a diagnosis of OC. The authors stated that the majority of women with obstetric cholestasis have serum bile acid concentrations of less than 100 micromolL and can probably be reassured that the risk of stillbirth is similar to that of pregnant women in the general population provided repeat bile acid testing is carried out until delivery.
2 Total serum bile acid levels are slightly higher in pregnant than in nonpregnant women mean SD 66 03 μmolL vs 57 04 μmolL 16 and levels up to 110 μmolL are accepted as normal in late gestation. After birth women should be offered follow-up to ensure that LFTs have returned to normal. Role of bile acid measurement in pregnancy 107 Canalicular secretion and formation of bile Bile salt uptake Bile salts are taken up into the hepatocytes from the liver sinusoids by at least two energy-dependent speci c proteintransportersSodium taurocholate co-transporting polypeptide NTCPwhichisdependentonthetransmembrane.
Objective Obstetric cholestasis OC is a liver disorder characterised by pruritus and elevated serum bile acids SBA that affects one in 200 pregnant women.
This is the most common symptom. With ICP the bile flow begins to. Bile Salts 40. 2012 Mar1194493-8PMID22251417 Lee RH et.
